Results in 48 – 72 Hours

In chronic patients (average 15.7 months) Actisound is proven to reduce pain and inflammation within 48-72 hours and provide full recovery of soft tissue injuries within 12 weeks, all without breaking the skin. The ITU technology can initially be used to treat Plantar Fasciitis, Lateral Epicondylitis, and other soft tissue injuries.

Surgery without Surgery

The completely non-invasive treatment acts like an invisible scalpel and can be performed in your office setting. The procedure takes only about 10 minutes and works without the complications or recovery time associated with minimally invasive procedures or traditional surgeries requiring an incision.

Designed For Licensed Professionals

Actisound is CE marked and available in the European Economic Area to licensed practitioners including: Orthopedic Surgeons, Foot and Ankle Surgeons, Podiatrists, Sports Medicine Physicians, Physical Medicine and Rehabilitation Physicians, Rheumatologists and Primary Care Physicians. Interested physicians can reach out for more information here. This product is not currently cleared for sale in the United States.

Help Your Chronic Pain Patients Avoid Surgery


Actisound’s Intense Therapeutic Ultrasound (ITU) from Guided Therapy Systems acts like an invisible scalpel— working beneath the surface of the skin — precisely delivering small thermal ablations to tendons, ligaments, and other soft tissue to stimulate collagen growth and the regeneration of connective tissue. Unlike other energy sources such as laser, microwave and radio frequency, ultrasound is the only energy source that can penetrate safely through intervening tissue AND be focused to a specific point and shape within the body. This allows physicians the unique ability to deliver treatments directly at the point of injury—up to depths of 13mm—without ever opening the patient.

The small thermal ablations in turn, initiate the healing cascade within the body, restarting and enhancing the production of endogenous growth factors in connective tissue through three phases of activity:


Disruptive cells release “growth factors”


Angiogenesis and fibroblasts migrate, deposit type III collagen

Maturation & Remodeling Phase:

Type III collagen converts to type I and elastin fibers, along with formation of collagen fiber cross linkage

The Actisound engineering team designed this product to be robust, safe, and easy to use. The control system and attached applicators for variety of clinical indications are mobile, have a simple user interface, and require little training for use. Actisound uses high-powered internally focused piezoelectric crystals, which create ultrasound beams passing through acoustic liquids and acoustically matched membrane coupled to the skin. The beam focused below the skin spares intervening tissue and precisely targets the clinically relevant organs to be repaired.

Clinical Evidence

In addition to a significant body of pre-clinical testing, Actisound has been used in three multi-center clinical studies for the treatment of chronic plantar fasciitis and epicondylitis. More than 100 subjects have been treated in the course of these studies in addition to millions who have been treated using Guided Therapy’s System ITU technologies for other applications. In all three studies, more than 80% of subjects enjoyed a reduction in pain combined with increased function and mobility. Based on the clinical evidence, Actisound’s high efficacy, combined with its quick, easy-to-apply non-invasive treatments will provide an attractive new alternative to Physicians early in the conservative treatment path. Contact us for more information on Actisound’s body of clinical evidence.

Actisound is currently undergoing further testing to expand applications for use and support FDA 510(k) clearance.

Publications and Clinical Reports

Intense Therapeutic Ultrasound for Pain Relief
– Michael H. Slayton, PhD, Bob Baravarian, DPM, Richard C. Amodei, RDMS, Keegan B. Compton, MS, Dallin Neil Christensen, MD, Ashley McNelly, MD, and L. Daniel Latt, MD, PhD

Advances in Orthopaedics and Sports Medicine
– Michael H. Slayton, Richard C. Amodei, Keegan B. Compton

Structural and functional assessment of intense therapeutic ultrasound effects on partial Achilles tendon transection
– Jennifer K. Barton, Photini S. Rice, Caitlin C. Howard, Jen W. Koevary, Forest Danford, et al.

Musculoskeletal Clinical Applications of Intense Therapy Ultrasound (ITU):
Part 1. Clinical Study for Chronic Plantar Fasciitis
– Slayton, M.H., Amodei, R.C., Compton, K.B., McNelly, A., Latt, D.

Musculoskeletal Clinical Applications of Intense Therapy Ultrasound (ITU):
Part 2. Initial Results of Clinical Study for Chronic Lateral Epicondylitis
– Slayton, M.H., Amodei, R.C., Compton, K.B., McNelly, A., Latt, D.

Retrospective and Introspective Analysis of Plantar Fascia by Ultrasound Imaging Patients Diagnosed with Plantar Fasciitis/Fasciosis, Journal of American Podiatric Medical Association.
– Slayton, M.H., Amodei, R.C., Compton, K.B., Cicchinelli, L.D.

Musculoskeletal Treatments Using Intense Therapy Ultrasound: Clinical Studies for Chronic Plantar Fasciitis and Lateral Epicondylitis, IEEE-NIH, Cancun, Mexico, November 2016
– Slayton, M.H., Amodei, R.C., Compton, K.B., Latt, D., Kearney, J.

Intense Therapy Ultrasound (ITU) for the Treatment of Chronic Plantar Fasciitis: preliminary Results of Clinical Study, 37th Annual Conference if IEEE Engineering in Medicine and Biology, Milan, Italy, August 2015
– Slayton, M.H., Amodei, R.C., McNelly, A., Latt, D.

Feasibility of Modulating Healing Tissue Response by ITU (Intense Therapy Ultrasound) in Musculoskeletal Tissue, ASLMS Annual Conference, April 2014
– Slayton, M.H., Barton, J. K.

Feasibility of Modulating Healing Tissue Response by ITU (Intense Therapy Ultrasound) in Musculoskeletal Tissue, ASLMS Annual Conference, April 2014
– Slayton, M.H., Barton, J. K.

Healing tissue response with ITU (Intense Therapy Ultrasound) in musculoskeletal tissue, feasibility study, Ultrasonics Symposium (IUS) 2014 IEEE International, pp. 1654-1657, DOI: 1109/ULTSYM. 2014.0410.
– Slayton, M.H., Barton, J. K.

Intense Therapeutic Ultrasound for Chronic Plantar Fasciitis Musculoskeletal Pain Reduction
– University of Arizona: University of Arizona IRB #: 1404296558R002 Daniel Latt, MD, Ph.D.

Intense Therapeutic Ultrasound for Chronic, Subcutaneous Lateral Epicondylitis Musculoskeletal Pain Reduction
– The More Foundation/The Core Institute: Western IRB #: 20150654 John Kearney, MD

Intense Therapeutic Ultrasound for Chronic Plantar Fasciitis Musculoskeletal Pain Reduction
– University Foot and Ankle Institute: Western IRB #: 20160753 Bob Baravarian, DPM

Intense Therapeutic Ultrasound for Chronic Lateral Epicondylitis Pain Reduction
– Michael H Slayton1, John A Kearney2, Richard C Amodei1 and Keegan B Compton

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Clinician Information

Practice/Office Information

33 South Sycamore Street
Mesa, Arizona 85202
United States

London BioScience
Innovation Centre
2 Royal College Street
London, England NW1 0NH

Actisound Europe
Windmolen 22
7609 NN Almelo
The Netherlands